Tag Archive : stem cell therapy

/ stem cell therapy

Four months after treating them, Yasuhiro Shiga, MD, PhD, checked on his rats. Walking into the lab, he carried minimal expectations. Treating spinal cord injuries with stem cells had been tried by many people, many times before, with modest success at best. The endpoint he was specifically there to measure — pain levels — hadn’t seemed to budge in past efforts.

“Well, it doesn’t seem to be working. I don’t see any real change in pain behavior in any of the groups,” said Shiga, a visiting scholar at University of California San Diego School of Medicine, apologetically, as he walked into the office of his supervisor, Wendy Campana, PhD, professor in the Department of Anesthesiology and Program in Neuroscience.

But, to Campana’s surprise, he continued, almost as an after-thought.

“Although … some rats are actually really moving.”

The difference for those rats was this: Before delivering them into the spinal cord injury site, Shiga and Campana had conditioned stem cells with a modified form of tissue-type plasminogen activator (tPA), a drug commonly used to treat non-hemorrhagic stroke.

Full story at Science Daily

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it’s safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report.

However, the trial does provide evidence that giving the therapy early — within the first 36 hours after stroke symptoms surface — may enhance physical recovery by reducing destructive inflammation as well as the risk for serious infections and that these benefits might continue to surface many months down the road, they report in the journal Lancet Neurology.

Stroke is a leading cause of long-term disability and the leading preventable cause of disability, according to the American Heart Association.

Full story of stem cell therapy for stroke patients at Science Daily