The results of “The Japan Statin Treatment Against Recurrent Stroke (J-STARS)” study led to the hypothesis that statins reduce the occurrence of strokes due to larger artery atherosclerosis.
J-STARS examined whether pravastatin, a traditional statin widely used in the clinic, reduces the recurrence of strokes and respective subtypes in non-cardioembolic stroke patients. The study also examined whether the use of pravastatin favorably impacts the occurrence of other vascular events, and stroke-related functional outcomes were explored.
Statins are widely used to reduce cholesterol levels in blood. High cholesterol levels are associated with cardiovascular diseases such as strokes, so statins are thought to be beneficial for stroke prevention. However, these findings are obtained from patients without prior stroke, and the preventive effect is less robust in patients with prior stroke.