Researchers at the University of Basel have discovered a factor that could support the early detection of neurodegenerative diseases such as Alzheimer’s or Parkinson’s. This cytokine is induced by cellular stress reactions after disturbances of the mitochondria, the “cell’s power plants,” as neuropathologists write in the journal Cell Reports.
The normal functioning of human cells is based on the coordinated interaction of different cellular organelles. In many cases, an impaired communication between these organelles will lead to the activation of a stress response to ensure the survival of affected cells. A research group was able to demonstrate this in detail for brain neurons. The group is headed by Prof. Dr. Stephan Frank from the Institute of Medical Genetics and Pathology at the University of Basel and University Hospital of Basel; the universities of Cambridge (UK) and Padua (Italy) were also involved.
The neuropathologists were able to show that impairments on the level of mitochondria, commonly known as the “cell’s powerhouses,” also affect neighboring organelles, such as the so-called endoplasmic reticulum. A consecutively activated stress reaction leads to the release of fibroblast growth factor-21 (FGF21) by nerve cells with disturbed mitochondria. The Basel researchers further observed that the same substance is also induced in various models of neurodegenerative disorders, where it can be detected prior to neuronal cell death.
As Kathy Helgerson slipped the pair of MINDVR goggles over Rita Strauss’ head, the reaction was instant.
“It looks like Midnight!” Strauss, 87, said with glee. “My tomcat.”
It’s moments like this that lead Helgerson, Strauss’ daughter and founder of “Simple Steps to Technology” to say she has “the best job in the world.”
“It is so powerful, I can’t even tell you,” Helgerson said, tears welling in her eyes at the spark of recognition from her mom, who has Alzheimer’s. “It brings up those memories of the past. … If you had asked my mom about (the cat) normally, she would have forgotten about it.”
Nursing homes in the U.S. are administering antipsychotic drugs to tens of thousands of elderly residents each week who do not have the diagnoses for which the drugs are prescribed and who are not giving their “free and informed consent,” according to a new Human Rights Watch report.
In a report released Monday titled, “They Want Docile,” the group states that some 179,000 residents of long-term nursing homes across the country are given antipsychotic drugs each week that are not appropriate for their condition. The report says the drugs are used for their sedating side effects, which make patients with dementia and Alzheimer’s disease easier to manage.
“People with dementia are often sedated to make life easier for overworked nursing home staff, and the government does little to protect vulnerable residents from such abuse,” Hannah Flamm, a New York University law school fellow at Human Rights Watch told The Guardian.
A paper published today in the New England Journal of Medicine reports that solanezumab, a monoclonal antibody-based treatment for Alzheimer’s disease developed by Eli Lilly that targets amyloid plaques, did not significantly slow cognitive decline.
Columbia University Irving Medical Center (CUIMC) led the multicenter study.
Researchers have proposed that Alzheimer’s disease is caused by the buildup of a sticky protein called beta-amyloid. According to this ‘amyloid hypothesis,’ the protein forms plaques in the brain that damage and eventually destroy brain cells. Solanezumab was designed to reduce the level of soluble amyloid molecules before they aggregate.
According to the latest studies from the Alzheimer’s Association, someone develops dementia every 66 seconds. That means in the 10 minutes it takes to read this article, nine new cases will appear. This number is on the rise, too – by the middle of the century, experts predict one new case of the disease every 33 seconds.
Dealing with the implications of dementia is a terrible burden not only for the afflicted, but for the families who care for them. Few things in life are as painful as watching a loved one lose their mental faculties, and few things are as worrisome as leaving those affected on their own, even for a short time.
Smart home technology can help relieve that worry, if only by a small amount. While some medical alert companies have systems specifically designed to make independence easier for patients, these systems tend to cost exorbitant amounts of money – sometimes $150 per month or more. But an expensive system isn’t always the answer: Basic smart home components can provide safeguards and alerts. Here are the top smart home features to consider for these loved ones.
About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year, according to a new study by researchers at the UCLA Fielding School of Public Health.
The findings highlight the need to develop measures that could slow the progression of the disease in people who have indications of neuropathological changes that could eventually lead to Alzheimer’s dementia, said Ron Brookmeyer, professor of biostatistics at the UCLA Fielding School of Public Health and the study’s lead author. The country’s population is aging and with it comes a growing number of people with Alzheimer’s disease.
The study was published in the peer-reviewed Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association. The study is the first of its kind that has estimated the numbers of Americans with preclinical Alzheimer’s disease or mild cognitive impairment.
Research published Wednesday in Genome Medicine details a novel and promising approach in the effort to treat Alzheimer’s disease.
Brigham Young University professors Perry Ridge and John Kauwe led the discovery of a rare genetic variant that provides a protective effect for high-risk individuals — elderly people who carry known genetic risk factors for Alzheimer’s — who never acquired the disease.
In other words, there’s a specific reason why people who should get Alzheimer’s remain healthy. Study authors believe this genetic function could be targeted with drugs to help reduce the risk of people getting the disease.
As a clinical social worker and care coordinator at Montefiore Health System’s Center for the Aging Brain, I’ve learned that older adults face similar barriers when it comes to navigating health care. Many predict that by the year 2030, the amount of older American’s will double and account for a significant amount of our population. As this population continues to grow, it’s important that caregivers are aware of some common issues faced by older adults to ensure their loved ones receive the best care. Here are things to consider when planning for care.
According to the Alzheimer’s Association’s 2017 Facts and Figures, 37 percent of our population ages 85 and over will be diagnosed with Alzheimer’s; 17 percent of those ages 65 to 74 and 1 in 10 people over age 65 will also receive this diagnosis. Alzheimer’s disease is a health crisis that is not only affecting older American’s emotionally but also causing a financial crisis. Associated costs are climbing into the billions for both patients and their caregivers. Although there’s not a cure for the disease, preventive measures, such as regular physical activity and dieting, can be taken to reduce the chances of an Alzheimer’s diagnosis.
Picture a bare wire, without its regular plastic coating. It’s exposed to the elements and risks being degraded. And, without insulation, it may not conduct electricity as well as a coated wire. Now, imagine this wire is inside your brain.
That’s what happens in many diseases of the nervous system, such as multiple sclerosis (MS), spinal cord injuries, stroke, neonatal brain injuries, and even Alzheimer’s disease.
Much like that bare wire, the nerve fibers in the brain lose their protective coating, called myelin, and become extremely vulnerable. This leaves the nerve cells exposed to their environment and reduces their ability to transmit signals quickly, resulting in impaired cognition, sensation, and movement.
It’s private and few people discuss it openly. Couples who’ve spent decades together as lovers and equals – husbands, wives and partners – increasingly take on the roles of caregiverand patient as Alzheimer’s disease progresses. Sex and emotional intimacy give way to an all-consuming responsibility. During those difficult months and years, the still-healthy partner may ache for someone with whom to talk, share a restaurant or movie date or have a physical relationship.
Little social support exists for married caregivers who seek an intimate partner. Issues of faith, or concern over of the reactions from other family members and friends, cause people to bottle up these desires, says Donna Schempp, a licensed clinical social worker and consultant at Family Caregiver Alliance.