New research suggests that having a family history of Alzheimer’s may impair cognition throughout a person’s lifetime, but it also identifies factors that could offset these adverse effects. The findings may enable people at risk to take active measures for delaying or even preventing this form of dementia.
Having a close relative with dementia is a known risk factor for Alzheimer’s disease.
In fact, it is one of the two most significant risk factors, together with age. Having a first-degree relative with Alzheimer’s raises relative risk by 30%, which means that a person’s existing risk goes up by almost a third.
Having a copy of the gene APOE4 that encodes the protein apolipoprotein E raises Alzheimer’s risk by threefold. Having both copies of the gene — which is a rare occurrence — increases the risk by 10 to 15 times.